Single-tube liquid biopsy overcomes tissue biopsy failure to give oncologist personalized treatment decision guidance in matter of days.
A southeastern oncologist treating a 66-year-old male with lung cancer was unable to obtain testing results due to the failure of the tissue biopsy from the tumor. The oncologist referred a blood sample to CIRCULOGENE for its expertise in personalized cancer testing. In less than a week, CIRCULOGENE was able to detect a genetic alteration and match the patient’s cancer with a specific therapeutic.
Using a single tube of blood, CIRCULOGENE’s technology tested for genetic alterations for four different applications, which indicate different treatment strategies:
- DNA Mutations
- RNA Fusions
- PD-L1 Expression
- MSI (microsatellite instability)
In under one week, CIRCULOGENE detected a PD-L1 expression greater than 50% and identified 47 ongoing trials for DNA mutations associated with this lung cancer. The oncologist immediately initiated Keytruda® (pembrolizumab) therapy for his patient.
“It is unclear what the original treatment decision would have been due to the lack of a tissue biopsy; however, using a single tube of blood, CIRCULOGENE provided personalized results, allowing the treating physician to get the patient on the right therapy in a matter of days, instead of weeks or months.”– Chen Yeh, Chief Scientific Officer