Somatic Mutations in Cancer-Free Individuals: A Liquid Biopsy Connection
Open Acc J Oncol Med 2018.
Somatic mutations have been perceived as the causal event in the origin of the vast majority of cancers. Advanced massively parallel, high-throughput DNA sequencing have enabled the comprehensive characterization of somatic mutations in a large number of tumor samples for precision and personalized therapy. Understanding how these observed genetic alterations give rise to specific cancer phenotypes represents an ultimate goal of cancer genomics. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics.
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