Precision Medicine

Technological advances combined with an improved understanding of the genetic basis of cancer has allowed individualized profiling that is revolutionizing personalized medicine and cancer treatment.

With minimal volumes of blood, CIRCULOGENE’s patented technology utilizes next-generation sequencing (NGS) and reverse-transcriptase (RT-PCR) to monitor thousands of known tumor mutations in the following scientifically established, cancer-associated genes:

Click here to read descriptions of individual genes.

50 SOMATIC DNA GENES TESTS

ABL1
AKT1
ALK
APC
ATM
BRAF
CDH1
CDKN2A
CSF1R
CTNNB1
EGFR
ERBB2
ERBB4
EZH2
FBXW7
FGFR1
FGFR2

FGFR3
FLT3
GNA11
GNAQ
GNAS
HNF1A
HRAS
IDH1
IDH2
JAK2
JAK3
KDR
KIT
KRAS
MET
MLH1
MPL

NOTCH1
NPM1
NRAS
PDGFRA
PIK3CA
PTEN
PTPN11
RB1
RET
SMAD4
SMARCB1
SMO
SRC
STK11
TP53
VHL
BRCA1 AND BRCA2*

HEREDITARY GENES

APC*
ATM*
BMPR1A**
BRCA1*
BRCA2*
BRIP*
CDK4
CDH1 * **
CDKN2A

CHEK2* **
EPCAM**
MLH1* **
MSH2* **
MSH6* **
MUTYH**
PALB2*
PMS2**
POLD1**

POLE**
PTEN* **
RAD51C*
RAD51D
SMAD4**
STK11* **
TP53* **
VHL

* = HBOC GENES TESTED
** = LYNCH GENES TESTED

RNA AND IMMUNOTHERAPY

ALK GENE FUSION
ROS1 GENE FUSION
PD-L1 EXPRESSION
MSI
NTRK (coming soon)

APPROXIMATELY 3,000 MUTATIONS TESTED INCLUDING:

EGFR EXON 18, G719X MUTATION
EGFR EXON 18, E709X MUTATION
EGFR EXON 18, DEL 18 MUTATION
EGFR EXON 19 DELETION/INSERTION
EGFR EXON 20 INSERTION
EGFR EXON 20, S7681 MUTATION
EGFR EXON 20, T790M MUTATION

EGFR EXON 21, L858R MUTATION
EGFR EXON 21, L861Q MUTATION
KRAS CODON 12, 13 OR 61 MUTATION
BRAF V600 MUTATION
MET EXON 14 SKIPPING
NRAS CODON 12, 13, OR 61 MUTATION